Determination of Antineoplastic Activity of Rohituka, Aphanamixis Polystachya (Wall) RN Parker in Hela Cells: Correlation with Clonogenicity and DNA Damage

Though many of the presently used anticancer drugs are originated or derived from plants, an attempt to the isolation and clinical usage of single compound has caused severe adverse side effects like, myelosuppression, alopecia, nausea, gastrointestinal, reproductive and nephrotoxicity. In addition, most of the modern chemotherapeutic agents have been reported to induce secondary malignancies due to their carcinogenic potential in patients receiving therapy [1]. This necessitates a continued search for newer novel natural products and/or their semisynthetic analogs that may be useful as potential cancer chemotherapeutic drugs in the hope that it will be possible to encounter an agent/s that will be highly effective in treating neoplastic disorders without any side effect or minimum side effects when compared to the synthetic drug/s [2].